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KMID : 0385219970070030029
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Korean Journal of Gerontology
1997 Volume.7 No. 3 p.29 ~ p.36
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Effect of reed root extract(RRE) on learning and memory impairment animal model SAMP8 strain - Ⅲ. Feeding effects of RRE on nuerotransmitters and their metabolites in SAMP8 brain
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Choi Jin-Ho
Kim Dong-Woo
Choi Jae-Sue
Han Young-Sil
Baek Yeong-Ho
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Abstract
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Female senescence-accelerated mouse(SAM)P8 as a learning and memory impairments animal model were fed experimental diets with reed root extract(RRE : Phragmites communis) of 250㎎/㎏ BW for 8 months. Feeding effects of RRE on passive avoidance test, Neurotransmitters and their metabolites, the ratios of HVA/DA and 5-HIAA/5-HT and monoamine oxidase-B(MAO-B) activity in brain of SAMP8 were evaluated. Biological active compounds in reed root extract(RRE) also were identified. Passive avoidance tests such as acquisition trial and retention test in RRE group were significantly higher(90% and 20%) than those in control group. Acetylcholinesterase (AChE) activity was significantly increased about 60% by long-term administration of RRE compared with control group. Serotonin(5-HT) level in RRE group was significantly decreased(about 20%) and homovanillic acid(HVA) level was significantly increased(about 20%) compared with control group, but dopamine(DA) and 5-hydroxyindole acetic acid(5-HIAA) levels showed almost no change in RGE group. The ratios of HVA/DA and 5-HIAA/5-HT in RRE group were higher(30%, respectively) than those of control group. Monoamine oxidase-B(MAO-B) activity in RGE group in brain of SAMP8 was significantly inhibited about 15%, but p-coumaric acid identified from red root extract was remarkably inhibited about 65% in 100㎍ concentration compared with control group. These results suggest that long-term administration of RRE may be increased passive avoidance test, acetylcholinesterase activity, resulting in a grater prevention of learning and memory impairments such as Alzheimer-type dementia.
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KEYWORD
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Alzheimer-type dementia, Acetylcholinesterase(AChE), Neurotransmitters and metabolites, Monoamine oxidase-B(MAO-B), Passive avoidance test, p-coumaric acid
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